Dan Levy

This study uses intravital imaging to analyze calcium dynamics in meningeal macrophages under homeostasis and during brain hyperexcitability, revealing niche-specific behaviors and signaling responses.

This study shows that activating astrocytes in the visual cortex of rats triggers meningeal nociception and migraine-like behaviors by increasing nociceptor activity and pain sensitivity.

This study investigates how meningeal afferents respond to locomotion-related deformations in a migraine model, finding that CSD enhances sensitivity to these deformations.

This study shows that P2X7 and Pannexin 1 signaling in meninges mediates mechanical sensitization of afferents after CSD, contributing to migraine headache.

This study shows that severe head injury or repetitive subconcussive impacts in rats lead to prolonged headache-like behaviors, which can be reduced by anti-CGRP treatment.

This study investigates sex differences in post-traumatic headache-like behaviors and treatment responses in female rats after mild closed head injury, finding prolonged hyperalgesia and reduced effectiveness of anti-CGRP treatment in females.

This study shows that intact mast cells are required for latent pain sensitization after mild head injury, suggesting potential therapeutic targets for post-traumatic headache.

This study investigates the relationship between cortical spreading depression (CSD)-evoked metabolic changes and meningeal afferent activation in migraine, finding that metabolic perturbations are dissociated from afferent activation and sensitization.

This study investigates whether CGRP receptor antagonism affects meningeal afferent activation from K+ stimulation or CSD, finding suppression of K+-induced activation but not CSD-induced sensitization.