Author

Eric J. Tomko

Washington University in St. LouisORCID 0000-0003-0634-443XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

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Ankita ChaddaiD· 1 shared Eric A. GalburtiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Ankita ChaddaORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintAug 3, 2026

Bulky lesions on the displaced strand stimulate DNA unwinding by dimeric UvrD-family helicases

Eric J. Tomko, Ankita Chadda, Eric A. Galburt

The paper shows that dimeric UvrD-family helicases unwind DNA more efficiently when bulky lesions are on the displaced strand, suggesting a model where one subunit interacts with the displaced strand to promote processive unwinding.

DOI 10.64898/2026.08.03.742518

DNA methylationexperimental assay

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