Eric A. Galburt

The paper identifies a new DarTG subfamily in E. coli that uses a helicase protein to promote ADP-ribosylation of DNA purines, expanding the known functions of helicases in bacterial immunity.

The paper shows that dimeric UvrD-family helicases unwind DNA more efficiently when bulky lesions are on the displaced strand, suggesting a model where one subunit interacts with the displaced strand to promote processive unwinding.

This study identifies a conserved dimerization mechanism in SF1A UvrD-family helicases, showing that the 2B domain mediates dimerization and activation across multiple species.

This study shows that STPK phosphorylation of DosR in Mtb reduces its transcriptional activity and alters its response to nitric oxide stress, highlighting a regulatory interaction between STPKs and TCSs.

This study quantifies rRNA transcription in Mtb, showing {sigma}A dominates over {sigma}B, with CarD and RbpA modulating superhelicity effects and N-terminal {sigma}A residues enhancing activity.

This study reports the first structures of a dimeric UvrD-family helicase, revealing the 2B subdomain's regulatory role in dimerization and activation.