Ankita Chadda

The paper shows that dimeric UvrD-family helicases unwind DNA more efficiently when bulky lesions are on the displaced strand, suggesting a model where one subunit interacts with the displaced strand to promote processive unwinding.

This study identifies a conserved dimerization mechanism in SF1A UvrD-family helicases, showing that the 2B domain mediates dimerization and activation across multiple species.

This study reports the first structures of a dimeric UvrD-family helicase, revealing the 2B subdomain's regulatory role in dimerization and activation.