Holger Müller

This paper introduces a crossed laser phase plate (xLPP) for cryoEM, demonstrating improved contrast and resolution in imaging biological samples.

The paper shows that laser phase-plate images of apoF and rubisco reveal unexpected structural heterogeneity, suggesting that specimen damage may be more prevalent than previously thought.

The paper identifies thermal magnetic field fluctuations as a resolution limit in transmission electron microscopy with phase plates and shows that redesigning the laser phase plate mitigates this issue.

This paper introduces ECORE, a label-free optical method for recording neuroelectric activities without photobleaching or phototoxicity, demonstrating its use in various cell types and brain slices.