Author

Apoorva Purohit

The Ohio State UniversityORCID 0000-0003-0664-6972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ana Laura López-SerranoiD· 1 shared Angelina Ramirez‐Navarro· 1 shared Hsiang-Ling HuangiD· 1 shared Isabelle DeschênesiD· 1 shared Krishna ChinthalapudiiD· 1 shared Rupam BiswasiD· 1 shared Sarah M. HeissleriD· 1 shared Xiaolin ChengiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

Ana Laura López-SerranoORCID

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1 paper

Recent·Most cited

Structural and Functional Mechanisms Underlying Activation Gate Dynamics and IFM Motif Accessibility in Human Nav1.5

Rupam Biswas, Ana Laura López-Serrano, Apoorva Purohit, Angelina Ramirez‐Navarro, Hsiang-Ling Huang, Xiaolin Cheng, Sarah M. Heissler, Isabelle Deschênes, Krishna Chinthalapudi

This study presents a cryo-EM structure of human Nav1.5 in an intermediate open state, revealing a new Na+ binding site and showing ion binding modulates IFM motif docking and inactivation kinetics.

Nature Communications · Feb 16, 2026Peer-reviewedBiophysics