Krishna Chinthalapudi

This study identifies 14-3-3 and S460 as critical for beta-adrenergic regulation of Nav1.5 at the cardiac intercalated disc, enhancing conduction velocity under sympathetic stimulation.

The paper presents the cryo-EM structure of human NM2B in the autoinhibited 10S conformation, revealing structural mechanisms of autoinhibition and implications for disease.

This study shows PRKAG2 variants cause cardiac hypertrophy and electrical changes in zebrafish, independent of glycogen storage, through AMPKγ2-myosin interactions.

This study investigates how specific MYH9 mutations affect NM2-A aggregation and intracellular dynamics, revealing differences in their molecular impact on cellular function and disease severity.

This study presents a cryo-EM structure of human Nav1.5 in an intermediate open state, revealing a new Na+ binding site and showing ion binding modulates IFM motif docking and inactivation kinetics.

This study investigates the structure and function of arginylated beta-actin, showing structural similarity to non-arginylated actin but altered interactions with myosin-II and effects on cellular processes.