Author

Isabelle Deschênes

The Ohio State UniversityORCID 0000-0002-1812-7267Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Assay:electronic health records· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angelina Ramirez‐Navarro· 2 shared Krishna ChinthalapudiiD· 2 shared Rupam BiswasiD· 2 shared Ana Laura López Serrano· 1 shared Ana Laura López-SerranoiD· 1 shared Apoorva PurohitiD· 1 shared Gea‐Ny TsengiD· 1 shared Hsiang-Ling HuangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Angelina Ramirez‐Navarro

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 26, 2026

14-3-3 Enables β-Adrenergic Regulation of the Cardiac Sodium Channel at the Intercalated Disc

Yang Zheng, Ana Laura López Serrano, Snizhana Chorna…·Isabelle Deschênes

This study identifies 14-3-3 and S460 as critical for beta-adrenergic regulation of Nav1.5 at the cardiac intercalated disc, enhancing conduction velocity under sympathetic stimulation.

DOI 10.64898/2026.10.23.761442

humanelectronic health records

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BiophysicsNature CommunicationsPeer-reviewedFeb 16, 2026

Structural and Functional Mechanisms Underlying Activation Gate Dynamics and IFM Motif Accessibility in Human Nav1.5

Rupam Biswas, Ana Laura López-Serrano, Apoorva Purohit…·Krishna Chinthalapudi

This study presents a cryo-EM structure of human Nav1.5 in an intermediate open state, revealing a new Na+ binding site and showing ion binding modulates IFM motif docking and inactivation kinetics.

1 citation

humancryo-EM

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