Sarah M. Heissler

Structural basis of nonmuscle myosin-2 autoinhibition mechanisms

The paper presents the cryo-EM structure of human NM2B in the autoinhibited 10S conformation, revealing structural mechanisms of autoinhibition and implications for disease.

Beyond Glycogen Storage: AMPKγ2 Regulates Cardiac Hypertrophy and Electrophysiology via Myosin Interaction

This study shows PRKAG2 variants cause cardiac hypertrophy and electrical changes in zebrafish, independent of glycogen storage, through AMPKγ2-myosin interactions.

Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific MYH9 Mutations

This study investigates how specific MYH9 mutations affect NM2-A aggregation and intracellular dynamics, revealing differences in their molecular impact on cellular function and disease severity.

Structural and Functional Mechanisms Underlying Activation Gate Dynamics and IFM Motif Accessibility in Human Nav1.5

This study presents a cryo-EM structure of human Nav1.5 in an intermediate open state, revealing a new Na+ binding site and showing ion binding modulates IFM motif docking and inactivation kinetics.

Structure and physiological investigation of arginylated actin

This study investigates the structure and function of arginylated beta-actin, showing structural similarity to non-arginylated actin but altered interactions with myosin-II and effects on cellular processes.