Molecular BiologybioRxivPreprint
Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells
Shengzhe Shang, Sangam Giri Goswami, Torry Li…·Gordon D. Ginder
This paper identifies critical interaction domains in the GATAD2A-CHD4 complex within the MBD2-NuRD complex that, when disrupted, increase fetal hemoglobin (HbF) expression in adult erythroid cells.
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