Author

Gordon D. Ginder

Virginia Commonwealth UniversityORCID 0000-0001-9875-3198Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

David C. WilliamsiD· 2 shared Torry Li· 2 shared Albert A. BowersiD· 1 shared Christopher R. TravisiD· 1 shared Dhanushi Dedakia· 1 shared Jarrett M. PeltoniD· 1 shared Jie Ren· 1 shared Mikhail G. DozmoroviD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

David C. WilliamsORCID

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2 papers

Recent·Most cited

Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells

Shengzhe Shang, Sangam Giri Goswami, Torry Li, Wang He, Christopher R. Travis, Mikhail G. Dozmorov, David C. Williams, Gordon D. Ginder

This paper identifies critical interaction domains in the GATAD2A-CHD4 complex within the MBD2-NuRD complex that, when disrupted, increase fetal hemoglobin (HbF) expression in adult erythroid cells.

bioRxiv · Jul 20, 2026 · PreprintMolecular Biology

Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex

David C. Williams, Jie Ren, Torry Li, Jarrett M. Pelton, Dhanushi Dedakia, Robert K. McGinty, Gordon D. Ginder, Albert A. Bowers

The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.

bioRxiv · Jun 7, 2026 · PreprintBiophysics