David C. Williams

Exploring the bistable equilibrium of methylated CpG DNA recognition by the MBD2 protein

The paper uses molecular dynamics simulations and experimental assays to show MBD2 binds methylated CpG DNA with a bistable equilibrium, involving two stable conformations with different affinities.

Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells

This paper identifies critical interaction domains in the GATAD2A-CHD4 complex within the MBD2-NuRD complex that, when disrupted, increase fetal hemoglobin (HbF) expression in adult erythroid cells.

Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex

The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.