Xiangwei Zhao

CHART-seq enables ultra-fast, scalable full-length single-cell RNA sequencing with improved gene detection and isoform annotation compared to existing methods.

Decomap-seq improves spatial transcriptomics by enhancing transcript capture efficiency through structural optimization of probe design.

The paper develops a method to co-profile transcriptomes and proteomes of rare CSF-CTCs, revealing malignant dormancy and post-transcriptional buffering as key mechanisms of treatment resistance.

The paper introduces snCED-seq, a method for isolating high-quality nuclei from FFPE tissues, showing improved RNA retention and gene detection compared to traditional methods.

This study evaluates how fixation and storage times affect nuclear transcriptomic profiles in FFPE brain tissues, finding that fixation time has a greater impact than storage time.

This study uses single-nucleus RNA sequencing to identify PD-specific cell states in MPTP-induced mouse brains, revealing changes in astrocytes, endothelial cells, and medium spiny neurons.