Randy B Stockbridge

This study investigates how sodium and lithium regulate the fluoride exporter FEX, revealing structural and functional differences in their effects on channel activity and fluoride tolerance in yeast.

This study identifies fluoride's mechanism of killing Streptococcus mutans by inhibiting Clp protease, leading to uncontrolled competence cascade and cell lysis.

This study identifies the molecular mechanism of sodium-dependent fluoride export by FEX proteins using electrophysiology, cryo-EM, and simulations.

This study shows that genetic knockout of fluoride export proteins in pathogenic oral microbes reduces their fitness in biofilms, altering microbial composition and pathogenic properties.

The paper identifies peripheral mutations that enable promiscuous transport of quaternary ammonium antiseptics by SMR transporters, revealing that substrate preference changes through mutations outside the binding pocket.