Grayson L. Chadwick

This paper identifies novel radical SAM enzymes involved in archaeal lipid methylation, desaturation, and hydroxy-GDGT biosynthesis using three archaeal species.

This study shows that methanogenic archaea use an ambiguous genetic code where the stop codon UAG can encode pyrrolysine, and that Pyl biosynthesis is regulated to manage this ambiguity.

This study demonstrates that MMP16 is the primary CoM synthase in Methanosarcina acetivorans, showing that its deletion leads to CoM-dependent growth and transcriptomic changes, supporting its role as a bona fide ComF.