Dipti D. Nayak

This study identifies the methanol-specific methyltransferase complex as the source of large carbon and hydrogen isotope effects in methanol-driven methane production, showing these effects are consistent across isozymes and persist at low methanol concentrations.

This paper identifies component A2 as an ATPase essential for reductive activation of methyl-coenzyme M reductase (MCR) under anaerobic conditions.

This study identifies a family of archaeal hibernation factors that bind to ribosomes in tandem and protect them during dormancy.

This study investigates the modular genetic pathways for acetoclastic methanogenesis in Methanosarcina and Methanothrix species, showing that gene modules are not interchangeable between the two genera.

The paper identifies a novel archaeal transcription factor family, AmzR, that combines prokaryotic and eukaryotic regulatory features, functioning as a negative regulator of methanogenic growth.

This study investigates the roles of histones and NAPs in Methanosarcina acetivorans, showing that DBPs are not essential for growth but aid in recovery from stress or growth stasis.

This paper identifies novel radical SAM enzymes involved in archaeal lipid methylation, desaturation, and hydroxy-GDGT biosynthesis using three archaeal species.

This study manipulates Methanosarcina acetivorans growth rate via CRISPR to show isotopic composition of methane depends on MCR expression and growth rate.

The paper identifies divergent ribosomal RNA sequences in the PTC of archaea and determines their structure, revealing sequence variation and a novel hibernation factor.

This study shows that methanogenic archaea use an ambiguous genetic code where the stop codon UAG can encode pyrrolysine, and that Pyl biosynthesis is regulated to manage this ambiguity.

This study demonstrates that MMP16 is the primary CoM synthase in Methanosarcina acetivorans, showing that its deletion leads to CoM-dependent growth and transcriptomic changes, supporting its role as a bona fide ComF.

The paper identifies circular 23S rRNA in archaeal ribosomes, showing they are more abundant than linear forms and confirms their structure through sequencing and modeling.