Edgar T. Walters

This study shows that a cAMP signaling pathway can induce long-term hyperexcitability in nociceptors, which may contribute to persistent pain.

The paper shows that nociceptors exhibit latent hyperactivity after incision injury, which persists longer than behavioral pain indicators.

The paper investigates the mechanisms of spontaneous activity in nociceptor cell bodies, showing that high input resistance and background ion channel activity generate depolarizing spontaneous fluctuations linked to pain conditions.