Michael X. Zhu

This paper identifies DHHC21 as a STIM1 S-acyltransferase essential for SOCE and immune function, showing its role in ALPS and related diseases.

The paper reports cryo-EM structures of human P2X2/3 heterotrimers in different functional states, revealing asymmetric ligand recognition and allosteric coupling mechanisms.

The paper identifies NPY+ interneurons in the ventral hippocampus that regulate memory extinction through distinct sub-ensembles via fast and slow inhibition.

The study identifies ATP-sensitive P2X5 isoforms and transcript variants in multiple species, challenging the assumption of their ATP-insensitivity.

This study identifies a specific LEC-vCA1 pathway that uses low gamma-band oscillations to facilitate fear extinction and shows its therapeutic potential through DBS and tACS in a PTSD mouse model.

The paper shows that nociceptors exhibit latent hyperactivity after incision injury, which persists longer than behavioral pain indicators.

The paper investigates the mechanisms of spontaneous activity in nociceptor cell bodies, showing that high input resistance and background ion channel activity generate depolarizing spontaneous fluctuations linked to pain conditions.

This study identifies phosphatidylserine (PS) as a critical lipid for ASIC1a synaptic targeting and function through electrostatic interactions.

The paper shows that forgetting of extinction memory involves a dynamic shift in the connectivity of engram circuits between the mPFC, BLA, and vHPC.

This study shows that TPK deficiency in the brain leads to Alzheimer's pathology in mice and is specific to AD in humans.