Brian L. Vander Ley

The paper shows that a single edited CD46 allele in cattle reduces susceptibility to BVDV in heterozygous state, despite functional wild-type allele expression.

The paper describes the creation of a gene-edited calf with reduced susceptibility to BVDV through CD46 modification, showing no adverse effects and confirming the effectiveness of the approach.

The paper evaluates a commercial test for estimating genetic risk of bovine congestive heart failure, finding it efficient and accurate with reference DNA but less so with rapid extraction kit DNA.

The paper constructs structural variant-based pangenomes from haplotype-resolved bovine assemblies and identifies variants potentially affecting phenotype.

This study uses trio binning to assemble chromosome-length haplotigs for yak and cattle from an F1 hybrid, achieving high continuity and phasing accuracy.