Tad Stewart Sonstegard

Inheritance of a Single Edited CD46 Allele Is Associated with Reduced Ex Vivo Susceptibility to Bovine Viral Diarrhea Virus

The paper shows that a single edited CD46 allele in cattle reduces susceptibility to BVDV in heterozygous state, despite functional wild-type allele expression.

Genomic Insights into the Population History and Adaptive Traits of Latin American Criollo Cattle

This study uses whole-genome sequencing and SNP arrays to analyze Criollo cattle from Colombia and Venezuela, revealing African and Asian admixture and selection signatures linked to adaptive traits.

First gene-edited calf with reduced susceptibility to a major viral pathogen

The paper describes the creation of a gene-edited calf with reduced susceptibility to BVDV through CD46 modification, showing no adverse effects and confirming the effectiveness of the approach.

The origin of domestication genes in goats

This study identifies introgression and selection events in goat domestication, linking them to immune and behavioral genes.

The Bovine Genome Variation Database (BGVD): Integrated Web-database for Bovine Sequencing Variations and Selective Signatures

The paper introduces BGVD, a database for bovine genomic variations and selection signatures, enabling data retrieval and visualization for cattle genomics research.

Base pair editing of goat embryos: nonsense codon introgression into FGF5 to improve cashmere yield

This study uses base editing in goat embryos to introduce nonsense mutations in FGF5, improving cashmere yield with minimal off-target effects.