Author

Aspen M. Workman

Agricultural Research ServiceORCID 0000-0003-2852-3519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Brian L. Vander LeyiD· 2 shared Michael P. HeatoniD· 2 shared Tad Stewart SonstegardiD· 2 shared Alexandria C Krueger· 1 shared Alexandria P SnideriD· 1 shared Daniel F. CarlsoniD· 1 shared Dennis A. Webster· 1 shared Erin E. Jobman· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Brian L. Vander LeyORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 1, 2026

Inheritance of a Single Edited CD46 Allele Is Associated with Reduced Ex Vivo Susceptibility to Bovine Viral Diarrhea Virus

Aspen M. Workman, Alexandria C Krueger, Michael P. Heaton…·Brian L. Vander Ley

The paper shows that a single edited CD46 allele in cattle reduces susceptibility to BVDV in heterozygous state, despite functional wild-type allele expression.

DOI 10.64898/2026.08.31.748238

whole-genome sequencingstatistical model

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GenomicsPNAS NexusPeer-reviewedMay 1, 2023

First gene-edited calf with reduced susceptibility to a major viral pathogen

Aspen M. Workman, Michael P. Heaton, Brian L. Vander Ley…·Tad Stewart Sonstegard

The paper describes the creation of a gene-edited calf with reduced susceptibility to BVDV through CD46 modification, showing no adverse effects and confirming the effectiveness of the approach.

55 citationstop 1%

experimental assay

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