Systems BiologybioRxivPreprint
A global genetic interaction map of a human cell reveals conserved principles of genetic networks
Maximilian Billmann, Michael Costanzo, Xiang Zhang…·Charles M. Boone
The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.
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