Tian Xia

Sum-h2, enabling genetic discovery for deep learning-derived phenotypes through a fast evaluation framework and arena of performance

The paper introduces sum-h2, a fast framework for evaluating genetic discovery from deep learning-derived phenotypes using heritability measures, and establishes a Genetic Discovery Arena for benchmarking.

The emergent mental operation of the learning brain

The paper tracks five-year longitudinal data of children learning abacus-based mental calculation to show how sustained practice reconfigures whole-brain states and enables complex skill acquisition.

Replicability of unsupervised deep learning derived image phenotypes

This study evaluates the replicability of unsupervised deep learning image phenotypes across different models, data splits, and cohorts, finding significant stability and biological relevance.

Learning dynamics of unsupervised deep learning reveal epoch-specific genetic architectures of brain morphology

The paper uses deep learning dynamics to uncover epoch-specific genetic architectures of brain morphology from UK Biobank data.

Learning heritable multimodal brain representation via contrastive learning

This paper introduces a multimodal contrastive learning framework to derive heritable brain representations from paired T1- and T2-weighted MRIs, improving genetic discovery and revealing shared biological targets.

A biofidelic Goat Model of Traumatic Optic Neuropathy with Optic Canal Fracture via Transnasal Endoscopy

This paper develops a goat model of traumatic optic neuropathy with optic canal fracture to better study the condition and its effects.

Natural language processing models reveal neural dynamics of human conversation

This study uses deep learning models to analyze neural activity during conversation, showing distributed and context-dependent patterns for speech production and comprehension.

The immunogenomic landscape of cattle

This paper presents a high-quality cattle genome assembly with improved continuity and completeness, revealing the highest known immune gene diversity in mammals.

Structural basis of peptidomimetic agonism revealed by small molecule GLP-1R agonists Boc5 and WB4-24

This paper reports cryo-EM structures of small molecule GLP-1R agonists Boc5 and WB4-24, revealing a novel binding pocket and mechanism for peptidomimetic agonism.

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

This paper develops a cold-protective treatment for traumatic optic neuropathy using a clinically relevant animal model, showing that combined hypothermia and cold protection reduces inflammation and metabolic stress without cellular damage.

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

The paper reports cryo-EM structures of GLP-1R with ago-allosteric modulators, revealing their mechanism of action and providing insights for therapeutic design.