Author

Lavania Joseph

National Health Laboratory ServiceORCID 0000-0003-0734-7149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:variant effect prediction· 2 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Derrick W. CrookiD· 3 shared Jeffrey KnaggsiD· 3 shared Philip William FowleriD· 3 shared Shaheed Vally OmariD· 3 shared Tim PetoiD· 3 shared Ajit LalvaniiD· 2 shared Alexander S. LachapelleiD· 2 shared Ana Lúıza Gibertoni CruziD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Derrick W. CrookORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyMicrobial GenomicsPeer-reviewedJun 18, 2025

An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in M. tuberculosis using a reproduciblealgorithmic approach.

Dylan Adlard, Lavania Joseph, Hermione J. Webster…·Philip William Fowler

The paper develops an automated method to predict bedaquiline resistance in M. tuberculosis using a reproducible algorithmic approach, achieving high sensitivity and specificity in variant classification.

6 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GenomicsNature CommunicationsPeer-reviewedJan 12, 2024

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

Ivan Barilar, Simone Battaglia, Emanuele Borroni…·Guy Edward Thwaites

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

56 citationstop 1%

humanwhole-genome sequencing

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GenomicsMolecular Biology and EvolutionPeer-reviewedMar 10, 2020

GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes

Daniel J. Wilson, Derrick W. Crook, Tim Peto…·Dick van Soolingen

GenomegaMap estimates genome-wide dN/dS ratios across 10,209 tuberculosis genomes to identify selection pressures shaping the pathogen's evolution.

48 citations

humanwhole-genome sequencing

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