This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

Nature Communications · Jan 12, 2024Peer-reviewedGenomics

The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex

Roger Vargas, Luca Freschi, Andrea Spitaleri, Sabira Tahseen, Ivan Barilar, Stefan Niemann, Paolo Miotto, Daniela María Cirillo, Claudio Umberto Köser, Maha Reda Farhat

The paper demonstrates epistatic interactions in Mycobacterium tuberculosis complex that can reverse antibiotic resistance, specifically showing that eis promoter mutations cannot confer resistance if paired with LoF mutations in the eis coding region.

Antimicrobial Agents and Chemotherapy · Aug 30, 2021Peer-reviewedGenomics

Transmission of pre-XDR and XDR-TB in the Mumbai Metropolitan Region, India

Viola Dreyer, Ayan Mandal, Prachi Dev, Matthias Merker, Ivan Barilar, Christian Utpatel, Kayzad Soli Nilgiriwala, Camilla S Rodrigues, Derrick W. Crook, Nerges Furdoon Mistry, Stefan Niemann

The paper analyzes whole genome sequencing data from tuberculosis strains in Mumbai to identify factors driving the pre-XDR and XDR-TB epidemic, finding lineage 2 strains are strongly associated with these resistant forms.

bioRxiv · Feb 2, 2021 · PreprintMolecular Biology

The global phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Matthias I. Gröschel, Conor Joseph Meehan, Ivan Barilar, Margo Diricks, Aitor Gonzaga, Matthias Steglich, Oscar Conchillo‐Solé, Isabell-Christin Scherer, Uwe Mamat, Christian F. Luz, Katrien De Bruyne, Christian Utpatel, Daniel Yero, Isidre Gibert, Xavier Daura, , Thomas Andreas Kohl

The paper analyzes global S. maltophilia strains to show genetic diversity and intra-hospital transmission.

Nature Communications · Apr 27, 2020Peer-reviewedGenomics