Guy Edward Thwaites

Whole blood transcriptional responses associated with bacterial burden in pulmonary tuberculosis

This study identifies a 1,093-gene module associated with Mtb burden in PTB, driven by neutrophils and monocytes, and highlights CNIH4 as a key predictor of bacterial burden.

Single-cell profiling of blood and cerebrospinal fluid in tuberculous meningitis

This study uses scRNA-seq to analyze CSF and blood from TBM patients, identifying inflammatory cell subtypes and altered metabolic pathways in CSF.

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

This study identifies gene modules, hubs, and pathways associated with TBM mortality using whole blood RNA sequencing and develops a 4-gene biomarker for predicting death from TBM.

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

Multidrug resistance plasmids underlie clonal expansions and international spread of Salmonella enterica serotype 4,,12,i:- ST34 in Southeast Asia

This study investigates the genomic structure and evolution of Salmonella ST34 in Southeast Asia, showing that multidrug resistance plasmids drive its clonal expansion and international spread.

A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasone

The paper uses Bayesian analysis to show the LTA4H TT genotype improves survival in TBM patients in Vietnam and Indonesia, but only when disease severity is not the primary cause of mortality.

GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes

GenomegaMap estimates genome-wide dN/dS ratios across 10,209 tuberculosis genomes to identify selection pressures shaping the pathogen's evolution.

Characterisation of gastrointestinal helminths and their impact in commercial small-scale chicken flocks in the Mekong Delta of Vietnam

The paper investigates gastrointestinal helminth prevalence and impact in small-scale chicken flocks in Vietnam, finding higher worm burdens in diseased birds and seasonal variation in colonization.

Genomic analysis of Mycobacterium tuberculosis reveals complex etiology of tuberculosis in Vietnam including frequent introduction and transmission of Beijing lineage and positive selection for EsxW Beijing variant

MULTILOCUS SEQUENCE TYPING REVEALS A UNIQUE CO-DOMINANT POPULATION STRUCTURE OF CRYPTOCOCCUS NEOFORMANS VAR. GRUBII IN VIETNAM

This study uses MLST to analyze Cryptococcus neoformans var. grubii isolates from Vietnam and Laos, revealing a unique intermediate population structure compared to other regions.

Whole genome sequence analysis of Salmonella Typhi isolated in Thailand before and after the introduction of a national immunization program

This study uses whole genome sequencing to analyze Salmonella Typhi isolates from Thailand before and after a national immunization program, showing that post-vaccine isolates were imported from neighboring countries rather than persisting locally.