Irena Jenickova

The paper shows that enhancing RNAi in testes via oocyte-specific Dicer does not rescue spermatogenic defects caused by Mili loss.

This study shows that Dicer{Delta}HEL1/wt mice exhibit increased endogenous siRNA levels and functional RNAi in vivo, providing a new model for studying mammalian canonical RNAi.

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

The paper investigates the roles of RNAi and piRNA pathways in mouse oocytes, finding that they redundantly target specific retrotransposons but are not essential for oocyte development.