BiophysicsbioRxivPreprint
Structural and Functional Insights into Alkaline-pH Sensing by the Alka Channel
Ting‐Wei Mi, Yuhang Wang, Yan Zhao, Yali Zhang
This study determines the cryo-EM structure of the Drosophila Alka channel, revealing a lysine residue as a molecular switch for alkaline pH sensing and identifying hydroxide ions as a new class of ion channel ligands.
DOI 10.1101/2025.10.29.685377