Author

Yan Zhao

Chinese Academy of SciencesORCID 0000-0002-4348-256XUnclaimed ORCID profile · follow to get notified of new preprints

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Yan Zhao11 papers · Beijing University of Chinese Medicine

Biology Disciplines

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Neuroscience· 2 Biophysics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Approach:machine learning (classical)· 1 Organism:non-human primate· 1

Frequent Co-Authors

Bei YangiD· 1 shared Beijia He· 1 shared Bin LiiD· 1 shared Daohua JiangiD· 1 shared Fan GuoiD· 1 shared Fei GaoiD· 1 shared Feiyan ZhaoiD· 1 shared Hongmei WangiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperNeuroscience

Bei YangORCID

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4 papers

Recent·Most cited

Substrate recognition and ion coupling mechanism of the human VIAAT

Yiqing Wei, Kunpeng Ma, Kun Hao, Qinru Bai, Jun Zhao, Xinyu Xie, Renjie Li, Qihao Chen, Yue Li, Hongmei Zhang, Zanxia Cao, Tuo Hu, Yan Zhao

The paper determines the structures of human VIAAT in multiple functional states and elucidates its substrate recognition and ion coupling mechanism.

Cell Research · Oct 30, 2026Peer-reviewedNeuroscience

Structural and Functional Insights into Alkaline-pH Sensing by the Alka Channel

Ting‐Wei Mi, Yuhang Wang, Yan Zhao, Yali Zhang

This study determines the cryo-EM structure of the Drosophila Alka channel, revealing a lysine residue as a molecular switch for alkaline pH sensing and identifying hydroxide ions as a new class of ion channel ligands.

bioRxiv · Oct 29, 2025 · PreprintBiophysics

The longitudinal single-cell panorama of cynomolgus monkey ovary throughout lifespan revealed a conserved ovarian clock between primates

Yan Long, Xin Long, Yan Zhao, Feiyan Zhao, Wan Tu, Qiuyun Yang, Jingjing Qian, Jinglei Zhai, Meijiao Wang, Yuqiong Hu, Beijia He, You‐Qiang Su, Xiangxiang Jiang, Fei Gao, Hongmei Wang, Fan Guo

The paper constructs a longitudinal single-cell atlas of cynomolgus monkey ovaries across 22 years, identifies a novel oocyte type, and develops a transcriptomic ovarian clock applicable to humans.

bioRxiv · Aug 14, 2023 · PreprintDevelopmental Biology

Gating mechanism of human N-type voltage-gated calcium channel

Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Yuan Tian, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao

The paper presents a cryo-EM structure of the human CaV2.2 complex, revealing the closed-state inactivation mechanism through the blocking-ball formed by the W-helix.

Cell Reports · Nov 1, 2021Peer-reviewedNeuroscience