Christopher M. Counter

This study identifies CDK8 inhibition as a therapeutic strategy for alveolar rhabdomyosarcoma by inducing myogenic differentiation and impairing tumor growth through a mechanism involving the Mediator kinase module, SAGA complex, and SIX4.

The paper identifies tissue-specific responses to rare codons in Drosophila, showing unique expression capabilities in testis and brain and a role for rare codons in restricting protein expression in the testis.

The paper identifies RpS21 as a signal strength-dependent regulator of the Ras/MAPK pathway using codon usage manipulation in Drosophila.