Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates
Liene Astica, Rafael D. Acemel, Henrike Schwarzenbacher…·Darío G. Lupiáñez
The paper investigates the evolution of CTCF's role in chromatin organization across species, finding that vertebrate CTCF enables loop extrusion but requires additional factors for full genome architecture.