Francisca Martinez Real

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

The paper investigates the evolution of CTCF's role in chromatin organization across species, finding that vertebrate CTCF enables loop extrusion but requires additional factors for full genome architecture.

This study uses deep learning and functional genomics to show that MEIS2 and TWIST1 co-regulation, along with changes in regulatory regions of PBX1, underlie bat forelimb specialization.

The paper identifies 3D regulatory hubs involved in sex determination using spatial auto-correlation analysis in mouse embryos.

The paper compares bat and mouse limb development using single-cell analyses to show how a conserved gene program is repurposed in bat wing formation.

The paper investigates how clustered-CTCF boundaries function in vivo, showing that individual CTCF sites can override other factors and that insulation strength modulates gene expression and phenotypes.

The paper compares transcriptomes of testes from two mammalian species during seasonal regression, identifying conserved changes in cell adhesion and immune response pathways.