Darío G. Lupiáñez

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

The paper investigates the evolution of CTCF's role in chromatin organization across species, finding that vertebrate CTCF enables loop extrusion but requires additional factors for full genome architecture.

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

The paper identifies supporting-like cells as an alternative steroidogenic lineage in mammals, conserved across amniotes, and shows their role in embryonic development and evolution.

The paper identifies 3D regulatory hubs involved in sex determination using spatial auto-correlation analysis in mouse embryos.

The paper compares single-cell transcriptomic data from turtles, mice, and chickens to show divergence in gonadal cell types and genetic programs across sex determination systems.

The paper compares bat and mouse limb development using single-cell analyses to show how a conserved gene program is repurposed in bat wing formation.

The paper investigates how clustered-CTCF boundaries function in vivo, showing that individual CTCF sites can override other factors and that insulation strength modulates gene expression and phenotypes.

The paper compares transcriptomes of testes from two mammalian species during seasonal regression, identifying conserved changes in cell adhesion and immune response pathways.

The paper uses crowdfunding to sequence a celebrity cat's genome, identifying mutations causing osteopetrosis and polydactyly, and highlights crowdfunding as a funding and communication tool.