Author

Daniel F. Zegarra-Ruiz

University of VirginiaORCID 0000-0003-0752-7238Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Katherine S Saldana-Morales· 2 shared Maricielo Vaella-Alarcon· 2 shared Miki KumeiD· 2 shared Silvia R. Davila-Paico· 2 shared Gillian L. McClennen· 1 shared Jin Din· 1 shared Luis F. SotoiD· 1 shared Olivia Bache· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

Katherine S Saldana-Morales

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 19, 2026

Systemic Autoimmunity Remodels Microbiota-Reactive CD4⁺ T Cell Immunity

Maricielo Vaella-Alarcon, Miki Kume, Silvia R. Davila-Paico…·Daniel F. Zegarra-Ruiz

This study shows systemic autoimmunity expands and differentiates microbiota-reactive CD4 T cells, which exacerbate autoimmunity through IL-21 and IFN-gamma mechanisms.

DOI 10.64898/2026.10.17.759871

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 12, 2026

TLR7-Dependent Autoimmunity Remodels Intestinal Immune Cell Dissemination

Katherine S Saldana-Morales, Miki Kume, Silvia R. Davila-Paico…·Daniel F. Zegarra-Ruiz

This study shows that TLR7-dependent autoimmunity alters intestinal immune cell dissemination, reducing lymphocytes and increasing myeloid cells, especially dendritic cells, in gut and systemic tissues.

DOI 10.64898/2026.10.05.756804

mouseexperimental assay

𝕏 PostBluesky