Author

Lena Nitsch

Max Delbrück CenterORCID 0000-0003-0775-1969Unclaimed ORCID profile · follow to get notified of new preprints

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Lena Nitsch1 paper

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Ansuman T. SatpathyiD· 3 shared Caleb A. LareauiD· 3 shared Leif S. LudwigiD· 3 shared Anshul Bharat KundajeiD· 2 shared Frank A. BuquicchioiD· 2 shared Jacob C. GutierreziD· 2 shared Patrick MaschmeyeriD· 2 shared Pauline KautziD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Ansuman T. SatpathyORCID

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3 papers

Recent·Most cited

GenomicsNaturePeer-reviewedMay 21, 2025

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

Michael Scherer, Indranil Singh, Martina Maria Braun…·Lars Velten

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

67 citationstop 1%

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GeneticsbioRxivPreprintApr 23, 2023

Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness

Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez…·Ansuman T. Satpathy

The paper identifies a synonymous mtDNA variant that affects codon-anticodon affinity and shows its impact on cellular fitness in immune cells.

5 citations

humanbulk RNA-seq

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GeneticsbioRxivPreprintNov 20, 2022

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells

Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio…·Leif S. Ludwig

The paper uses single-cell multi-omics to study how pathogenic mtDNA mutations are subject to purifying selection in immune cells from Pearson syndrome patients.

4 citations

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