Indranil Singh

This paper develops PLSTCs to expand AML LSCs and identifies clonal drivers of leukemogenesis and therapy response through genomic and single-cell analyses.

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

The paper develops STRACK to trace clonal gene expression and expansion dynamics in leukemia, showing pre-existing stem cell heterogeneity dictates clonal responses to cancer mutations.

This study shows reducing oxidative stress enhances ex vivo growth of human haematopoietic stem and progenitor cells in polymer-based cultures and enables efficient gene editing.