Author

Emily E. Prescott

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Agnieszka N. UrbanekiD· 3 shared Suman DeiD· 3 shared Anna OlerinyovaiD· 2 shared Heather MortiboysiD· 2 shared Hollie E. WareingiD· 2 shared J. Robin HighleyiD· 2 shared Marianne C. KingiD· 2 shared Tarja MalmiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Agnieszka N. UrbanekORCID

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Author profile →

3 papers

Recent·Most cited

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson's Disease

Emily E. Prescott, Jiapeng Wei, Emma F Garland, Agnieszka N. Urbanek, Francesco Capriglia, Willem Hendrik Molenkamp, David P Rhodes, Louise D Heywood, Aurélie Schwartzentruber, Elezabeth Stephen, Rachel M. Hughes, Oliver Bandmann, Mark O. Collins, Sara Snogerup Linse, Axel Abelein, , Suman De

This study identifies secondary nucleation of α-Synuclein as the key mechanism driving mitochondrial dysfunction and Lewy body formation in Parkinson's Disease.

bioRxiv · Sep 17, 2025 · PreprintNeuroscience

Molecular determinants of protein pathogenicity at the single-aggregate level

Agnieszka N. Urbanek, Emma F. Garland, Emily E. Prescott, Marianne C. King, Anna Olerinyova, Hollie E. Wareing, Nia Georgieva, Ellie L. Bradshaw, Svetomir B. Tzokov, Alexander Knight, A. I. Tartakovskii, Tarja Malm, J. Robin Highley, Suman De

This study investigates how variations in protein aggregate size, composition, and mutations affect biological functions in Alzheimer's and Parkinson's diseases.

Advanced Science · Jan 13, 2025Peer-reviewedBiochemistry

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

Zengjie Xia, Emily E. Prescott, Agnieszka N. Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy Barnes, Martyna M. Matuszyk, Eleni Dimou, Eric Hidari, Yu P. Zhang, Jeff Y. L. Lam, John S. H. Danial, , Suman De

The paper shows that apoE isoforms modulate Aβ aggregation, clearance, and toxicity in Alzheimer's disease, with implications for therapeutic strategies.

Nature Communications · Jun 1, 2024Peer-reviewedNeuroscience