Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer's disease
Agnieszka N. Urbanek, Alexander J. Dear, David Rhodes, Emma F Garland, Hollie E. Wareing, Harry J Baker, Willem Hendrik Molenkamp, Ruixin Zhang, Gefei Chen, Axel Abelein, Simon Bell, Juan Alberto Varela, Thomas C. T. Michaels, J. Robin Highley, Georg Meisl, , Suman De
This study identifies two distinct amyloid-β intermediates that drive Alzheimer's pathology and shows their suppression reduces plaque burden and improves cognition in mice.
bioRxiv · Oct 1, 2026 · PreprintBiophysics