Author

Alexandra M. Paulk

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Synthetic Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Organism:yeast· 1

Frequent Co-Authors

Chang C. LiuiD· 2 shared Brandon JewiD· 1 shared Christine Elaine TinbergiD· 1 shared CHRISTOPHER JAMES LANGMEADiD· 1 shared Debjani Bhar· 1 shared Gamze Ö. Çamdere· 1 shared Grant L. J. KelleriD· 1 shared Hua BaiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Chang C. LiuORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mapping the evolution of computationally designed protein binders

Miguel A. Alcantar, Alexandra M. Paulk, Shoeib Moradi, Debjani Bhar, Grant L. J. Keller, Tanmoy Sanyal, Hua Bai, Gamze Ö. Çamdere, Seog Joon Han, Mani Jain, Brandon Jew, Sezen Vatansever Inak, CHRISTOPHER JAMES LANGMEAD, Christine Elaine Tinberg, Irwin Chen, Chang C. Liu

This paper evolves computationally designed protein binders using in vivo hypermutation and maps their sequence-affinity landscapes to understand affinity improvements and mutation interactions.

bioRxiv · Oct 4, 2025 · PreprintSynthetic Biology

Rapidly inducible yeast surface display for antibody evolution with OrthoRep

Alexandra M. Paulk, Rory L. Williams, Chang C. Liu

This paper introduces an improved AHEAD platform using a synthetic β-estradiol induction system to accelerate antibody evolution in yeast.

ACS Synthetic Biology · Jul 25, 2024Peer-reviewedSynthetic Biology