Paolo Ruggerone

This study investigates how the allosteric inhibitor G6PDi-1 affects G6PD activity by combining biochemical assays and computational methods, revealing binding sites and allosteric effects that disrupt oligomerization.

This study identifies a cytosolic function of DNMT1 in regulating neuronal morphogenesis through microtubule dynamics and organelle trafficking, independent of its catalytic activity and nuclear localization.

This paper introduces a method to generate bound-like conformations of flexible, multi-domain proteins using unbound structures and binding site information, demonstrating its effectiveness on adenylate kinase.

MoNvIso predicts the correct protein isoform for mutations and builds structural models of wild-type and variant isoforms using gene names and mutation lists.