Cancer BiologyNature CommunicationsPeer-reviewed
Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry
Francesco Antonio Tucci, Rosa Pennisi, Damiano Cosimo Rigiracciolo…·Salvatore Pece
This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.
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