Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry
Francesco Antonio Tucci, Rosa Pennisi, Damiano Cosimo Rigiracciolo, Maria Grazia Filippone, R. Bonfanti, F. Romeo, Stefano Freddi, Elisa Guerrera, Chiara Soriani, Simona Rodighiero, Rosalind Helen Gunby, Giovanna Jodice, Francesca Sanguedolce, Giuseppe Renne, Nicola Fusco, , Salvatore Pece
This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.
Nature Communications · Dec 3, 2024Peer-reviewedCancer Biology