Author

Sonja Sievers

Max Planck Institute of Molecular PhysiologyORCID 0000-0003-0854-4507Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:perturbation response prediction· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Slava ZiegleriD· 3 shared Elisabeth Hennes· 2 shared Herbert WaldmanniD· 2 shared Alexandra Brause· 1 shared Alisa Reich· 1 shared Astrid Stefanie KahntiD· 1 shared Aubry K. MilleriD· 1 shared Aylin BiniciiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Slava ZieglerORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 24, 2026

Disrupting linearity of PROTAC scaffolds prevents off-target complex I inhibition

Nick Richert, Hana Nůsková, Jana Samarin…·Aubry K. Miller

The paper identifies that linear PROTAC scaffolds inhibit mitochondrial complex I, leading to ATP depletion, and proposes structural modifications to mitigate this off-target effect.

DOI 10.64898/2026.02.13.702718

humanproteomics

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Cell BiologyNature ChemistryPeer-reviewedJan 7, 2026

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

Elisabeth Hennes, Belén Lucas, Natalie S. Scholes…·Herbert Waldmann

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

18 citationstop 1%

humanproteomics

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ImmunologyChemistry - A European JournalPeer-reviewedFeb 11, 2025

Identification of small molecule enhancers of NK cell tumoricidal activity via a tumor microenvironment-mimicking co-culture assay

Aylin Binici, Elisabeth Hennes, Sandra Koska…·Herbert Waldmann

The paper identifies small molecules that enhance NK cell tumoricidal activity by counteracting immunosuppressive factors in the tumor microenvironment using a co-culture assay.

1 citation

experimental assaydrug response / drug discovery

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