Subha Kalyaanamoorthy

This study investigates how functionalized graphene quantum dots (GQDs) bind to Tau fibrils in Alzheimer's disease, identifying binding sites and showing that anionic GQDs preferentially bind to specific regions, potentially aiding in TA disaggregation.

The paper investigates how surface electrostatic networks mediate pH-dependent hydrophobic core remodeling in hisactophilin through protonation changes and residue interactions.

This paper introduces ESM-MSR, a model fine-tuned for predicting protein stability with multiple mutations, showing improved performance on several benchmarks.

This study investigates the HLA locus in PSP patients, finding associations between specific HLA alleles and disease risk, suggesting an autoimmune mechanism.

P4ward is an automated platform for modelling Protac ternary complexes, achieving high hit rates and improved pose ranking compared to existing methods.

This study evaluates six protein sequence likelihood models for thermostability prediction of protein variants, showing competitive performance compared to supervised methods and highlighting their complementary strengths.

The paper introduces a minimum reporting standard for multiple sequence alignments and provides a tool to assess alignment completeness.