Charles L. Brooks

The paper investigates how surface electrostatic networks mediate pH-dependent hydrophobic core remodeling in hisactophilin through protonation changes and residue interactions.

This paper identifies FAIM as an endogenous inhibitor of insulin amyloid formation by redirecting insulin toward non-toxic assemblies and reducing {beta}-sheet formation.

This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.

The paper identifies docking artifacts in large library screens by rescoring top-ranked molecules with orthogonal methods, finding that 39 predicted cheaters failed experimental testing while 57% of plausible actives showed inhibition.