MicrobiologybioRxivPreprint
The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of Adeno-Associated Virus Type 2 (wtAAV2) to cellular sites of DNA damage
Rhiannon R. Abrahams, Clairine I. S. Larsen, Raymond Ha, Kinjal Majumder
This paper identifies a mechanism by which wtAAV2 localizes to DNA damage sites via KLF4 and PARP1 interactions, showing that enhancing KLF4 binding improves rAAV vector performance.
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