Author

Rhiannon R. Abrahams

University of Wisconsin–MadisonORCID 0000-0002-8988-7976Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:Hi-C· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Clairine I. S. Larsen· 2 shared Kinjal MajumderiD· 2 shared David M. GammiD· 1 shared Divya SinhaiD· 1 shared Eda Erata· 1 shared Eleanor Hart· 1 shared Elizabeth K. Hofer· 1 shared Elliott M. Wilion· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Clairine I. S. Larsen

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CTCF regulates wild-type and recombinant AAV gene expression by shaping viral chromatin

Clairine I. S. Larsen, Rhiannon R. Abrahams, Rea Guertler, Elliott M. Wilion, Eda Erata, Zachary H. Sykes, Lorelei Stoica, Gopishankar Thirumoorthy, Divya Sinha, Richa Rai, Elizabeth K. Hofer, Eleanor Hart, David M. Gamm, Matthew S. Fuller, Kinjal Majumder

This study identifies a CTCF-binding element in the wtAAV2 genome that enhances rAAV transgene expression by shaping chromatin structure, offering a strategy to improve gene therapy vectors.

bioRxiv · Jun 3, 2026 · PreprintMicrobiology

The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of Adeno-Associated Virus Type 2 (wtAAV2) to cellular sites of DNA damage

Rhiannon R. Abrahams, Clairine I. S. Larsen, Raymond Ha, Kinjal Majumder

This paper identifies a mechanism by which wtAAV2 localizes to DNA damage sites via KLF4 and PARP1 interactions, showing that enhancing KLF4 binding improves rAAV vector performance.

bioRxiv · Feb 26, 2026 · PreprintMicrobiology