Kinjal Majumder

This study identifies a CTCF-binding element in the wtAAV2 genome that enhances rAAV transgene expression by shaping chromatin structure, offering a strategy to improve gene therapy vectors.

This paper identifies a mechanism by which wtAAV2 localizes to DNA damage sites via KLF4 and PARP1 interactions, showing that enhancing KLF4 binding improves rAAV vector performance.

This study shows HBV cccDNA localizes to DNA damage sites, inducing replication stress and contributing to liver cancer.

This study shows HPV31 genomes associate with active host chromatin regions, linking viral persistence to transcriptional activity and integration sites in cervical cancers.

This study shows that AAV2 genomes compete with host RPA for binding, causing replication stress and DNA damage, which suppresses viral gene expression.