Sam B. Choi

This paper introduces aspiration patch proteomics to profile single neurons in intact brain tissue, identifying over 1,000 proteins and enabling subtype-level proteome phenotyping without cell dissociation.

The paper develops a method to analyze proteins in single neuronal somas using patch-clamp electrophysiology combined with subcellular capillary electrophoresis mass spectrometry, identifying proteomic differences between neurons.

The paper introduces a data-dependent acquisition strategy for ultrasensitive proteomics, increasing protein detection in trace amounts from cultured neurons.