Abigail M. Polter

This paper introduces aspiration patch proteomics to profile single neurons in intact brain tissue, identifying over 1,000 proteins and enabling subtype-level proteome phenotyping without cell dissociation.

The paper investigates sex-specific relationships between stress coping strategies and avoidance behavior in mice under subchronic variable stress.

This study investigates sex-specific adaptations in VTA circuits under subchronic stress, finding reduced firing in female VTA dopaminergic neurons and increased inhibitory tone in both sexes.

The paper identifies distinct subpopulations of VTA dopamine neurons based on their glutamate and dopamine co-transmission and shows their differential roles in reward and aversion.

This study shows that glutamatergic synapses onto dorsal raphe serotonergic neurons increase in strength between postnatal days 6 and 21-23, with stable synaptic composition after P15.

The paper identifies a mu-opioid receptor gated circuit from VTA glutamate neurons to dopamine neurons that regulates opioid-seeking behavior.

The paper develops a method to analyze proteins in single neuronal somas using patch-clamp electrophysiology combined with subcellular capillary electrophoresis mass spectrometry, identifying proteomic differences between neurons.

The paper investigates how VTA glutamate neurons respond to reward and aversion cues through neurochemical inputs and neuronal activity.